By A. Simmons
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Additional resources for Hematology - A Combined Theoretical and Technical Appr.
Embryonic stem cells (ESC) have an unlimited proliferation capacity, and are pluripotent cells since they preserved the potential to differentiate into all cell types of the adult organism [1–3]. Adult tissues and organs of higher vertebrates are mostly constituted of fully differentiated and specialized cells forming the tridimensional layout and enabling the biological functions of those tissues/organs, and a rare population of speciﬁc stem cells with restricted ability to differentiate into the mature cell types constituting the tissues/organs where they reside .
Depending on the nature and/or abundance of this damage different DNA repair pathways are involved, that together, form an extremely complex, interacting defense platform against genotoxic damage (summarized in Fig. 3). The DDR is a signal transduction pathway that is primarily mediated by proteins of the phosphatidylinositol 3-kinase-like protein kinases (PI3KKs) family many of which have been described in the repair of DSBs including, ATM, ATR and DNA-PK. In addition to these, there are also the poly(ADP) ribose polymerase (PARP) family.
3 A simpliﬁed schematic of the DNA-damage response. This ﬁgure indicates an overview of the key protein kinases and signalling intermediates within eukaryotic cells that are activated following the detection of a double strand break and the various cellular choices that they dictate, principally via the tumour suppressor and transcription factor p53 3 Apoptosis 37 enter terminal differentiation via senescence (permanent cell cycle arrest) or to temporarily induce cell cycle arrest allowing DNA repair to occur.