By U. Costabel, R.M. du Bois, J.J. Egan, F.J.F. Herth
Diffuse parenchymal lung affliction (DPLD) represents a wide and heterogeneous staff of problems. even supposing new insights into the pathogenesis and new thoughts reminiscent of high-resolution-CT have resulted in a greater realizing of DPLD, medical administration is still a problem. This quantity is designed to turn into a important reduction within the prognosis and administration of DPLD. It starts off with common subject matters resembling a brand new class approach for DPLD, the final diagnostic strategy, and scientific review of the sufferer by means of radiology, histological styles and bronchoalveolar lavage. this can be by way of attention of a few uncomplicated elements akin to the genetics of DPLD, the foundations of granuloma formation, pulmonary fibrogenesis and vasculitis, in addition to novel remedy techniques. a wide a part of the publication includes disease-specific chapters, which debate granulomatous problems, idiopathic pulmonary fibrosis and different entities of idiopathic interstitial pneumonia, the collagen vascular ailments, drug-induced infiltrative lung disorder in addition to orphan diffuse lung illnesses together with Langerhans' cellphone histiocytosis, lymphangioleiomyomatosis and pulmonary alveolar proteinosis. detailed chapters on DPLD in young children and lung transplantation for end-stage fibrosis whole this entire booklet. Written by way of the world over recognized specialists, this well-organized quantity is usually recommended to a large viewers together with breathing physicians in education, perform and study in addition to radiologists and pulmonary pathologists
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Additional resources for Diffuse Parenchymal Lung Disease (Progress in Respiratory Research)
Am J Respir Crit Care Med 2000;161:646–664. 2 American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias: This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med 2002; 165:277–304. 3 Lynch JP III, Myers JL: Interstitial lung diseases; in Bone RC, Campbell GD Jr, Payne DK (eds): Bone’s Atlas of Pulmonary and Critical Care Medicine.
Whilst the typical HRCT pattern is highly predictive of a histological diagnosis of UIP, it should never be forgotten that in approximately one third of patients with IPF, the characteristic HRCT features of UIP are not present [17–19]. In a study of 98 patients, Flaherty et al.  showed that 26/73 patients with UIP on biopsy had CT appearances more akin to NSIP. This apparent discrepancy may, in part, reflect the fact that UIP and NSIP may coexist in the same patient, with the histological diagnosis critically dependent upon the site sampled.
17 White DA, Smith GJ, Cooper JA Jr, Glickstein M, Rankin JA: Hermansky-pudlak syndrome and interstitial lung disease: report of a case with lavage findings. Am Rev Respir Dis 1984;130:138–141. 18 Garcia CK, Raghu G: Inherited interstitial lung disease. Clin Chest Med 2004;25:421–433. 19 Torres VE, Bjornsson J, King BF, Kumar R, Zincke H, Edell ES, Wilson TO, Hattery RR, Gomez MR: Extrapulmonary lymphangioleiomyomatosis and lymphangiomatous cysts in tuberous sclerosis complex. Mayo Clin Proc 1995;70:641–648.