Download Diagnosis and Treatment of Gastroesophageal Reflux Disease by Michael F. Vaezi PDF

By Michael F. Vaezi

This quantity offers the newest advancements in analysis and therapy of sufferers with gastroesophageal reflux ailment (GERD) and those that stay refractory to traditional GERD cures. The e-book delineates the function of newly built endoscopic treatments in GERD and descriptions the easiest applicants for surgical fundoplication. themes because the dangers linked to GERD, way of life amendment in GERD and the function of H2RA and proton pump inhibitor treatment in treating reflux sickness also are explored.

Written by means of gurus within the box, Diagnosis and remedy of Gastroesophageal Reflux illness is a concise but finished source that's helpful for fundamental care companies, gastroenterologists, pulmonologists, surgeons and ENT specialists.

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Extra info for Diagnosis and Treatment of Gastroesophageal Reflux Disease

Example text

GERD occurs when the normal antireflux barrier between the stomach and the esophagus is impaired, either transiently or permanently. Therefore, defects in the esophagogastric barrier, such as lower esophageal sphincter (LES) incompetence, transient LES relaxations, and hiatal hernia, are the primary factors involved in the development of GERD [4]. Symptoms develop when the offensive factors in the gastroduodenal contents, such as acid, pepsin, bile acids, and trypsin, overcome several lines of esophageal defense, including esophageal acid clearance and mucosal resistance.

Yachimski epidemiologic data resulting in lower revised estimates of risk of progression from BE to EAC [46–48] may undermine justification for surveillance. A recent US-based case-control study reported no evidence of reduced EACrelated mortality among patients with BE who undergo endoscopic surveillance [63]. Alternatively, a recent European study assessed the impact of endoscopic surveillance on all-cause and EAC-specific mortality after stratifying according to endoscopic surveillance intervals.

Current Endoscopic Management Approaches to BE and EAC Prevention A triumvirate approach to management of BE has consisted of endoscopic screening of patients with GERD for diagnosis of BE, endoscopic surveillance of patients with established BE to identify progression to dysplasia and enable early cancer detection, and intervention (historically, surgical esophagectomy) for patients with HGD or early-stage cancer. Numerous factors including revised estimates of BE progression rates, increased recognition of the limitations of symptom-targeted screening and surveillance strategies, and the emergence of endoscopic therapy for BE HGD and stage T1 EAC have all had major impacts on endoscopic management of disease.

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