By Craig S. Kitchens MD, Barbara A Konkle MD, Craig M. Kessler MD
2014 BMA scientific publication Awards hugely recommended in inner drugs type!
A unique scientific focus makes Consultative Hemostasis and Thrombosis, third Edition your go-to consultant for speedy, sensible solutions on handling the whole variety of bleeding and clotting problems. Emphasizing real-world difficulties and ideas, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler supply all the medical suggestions you need to make optimum judgements on behalf of your sufferers and advertise the absolute best outcomes.
- Efficiently search for concise descriptions of every condition, its linked signs, laboratory findings, analysis, differential prognosis, and treatment.
- Get the most recent information
- Apply today’s most modern therapies, together with those who are fast turning into commonplace during this fast-changing field.
- Meet the wishes of particular sufferer groups with a brand new bankruptcy on Bleeding and the administration of Hemorrhagic issues in Pregnancy and an generally up-to-date bankruptcy on Thrombosis and Cancer.
- Zero in on key information with a brand new elementary layout, and all-new full-color format, considerable laboratory protocols, and at-a-glance tables and charts throughout.
- Access the total textual content and illustrations online - absolutely searchable - at www.expertconsult.com.
on scorching themes similar to Disseminated Intravascular Coagulation, Thrombophilia, scientific and Laboratory overview and administration, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia.
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Extra resources for Consultative Hemostasis and Thrombosis. Expert Consult - Online and Print
JAMA 296:397–402, 2006. 42. Dzik W: Reversal of drug-induced anticoagulation: old solutions and new problems. Transfusion 52:45S–55S, 2012. 3 Endothelium WILLIAM C. AIRD, MD Introduction The endothelium, which forms the inner cell lining of all blood vessels and lymphatics in the body, is a spatially distributed organ. The endothelium weighs approximately 1 kg in the average patient and covers a total surface area of 4000 to 7000 square meters. The endothelium is underappreciated as a clinically relevant organ.
Inhibitory antibodies that target and complex with these domains block these interactions and thus interfere with formation of the tenase complex of coagulation (Fig. 4-1). htm). Numerous point mutations and deletions have been identified in individuals with hemophilia B. These frequently result in the production of a defective, nonfunctioning, but immunologically detectable factor IX protein in the plasma (crossreacting material positive [CRM+]). html. CARRIER TESTING The most common methods for identification of carrier status are direct gene sequencing and linkage analysis to identify DNA polymorphisms.
39 The picture that emerges is one of heterogeneity layered upon heterogeneity. Indeed, if one were to survey endothelial cells from different sites of the vasculature, one would find that they mediate hemostasis via site-specific “formulas” of procoagulants and anticoagulants (Fig. 19,40 The site specificity of endothelial hemostatic function provides a foundation for understanding how systemic imbalances in coagulation are channeled into local thrombotic phenotypes (Fig. 41 The liver synthesizes a relatively consistent amount of serine proteases (factors XII, XI, X, IX, VII, and II), cofactors (factors V and VIII), fibrinogen, and anticoagulants (ATIII, protein C, protein S).