By Johanna L'age-Stehr
International experts in Microbiology, Infectious illnesses, inner medication, Cardiology Immunology, Pneumonolgy, Neurology and Epidemiology collected to this workshop to debate and improve interdisciplinary wisdom at the attainable etiological position of Chlamydia pneumoniae, a common human respiration an infection, within the pathogenesis of power inflammatory illnesses with significant public overall healthiness influence similar to: - atherosclerosis, - heart problems, - grownup onset bronchial asthma bronchiale, - persistent obstructive pulmonary diseases,- reactive arthritis,- Morbus Alzheimer and - a number of Sclerosis. present deficits and ambitions in standardisation of diagnostic instruments, uncomplicated and utilized learn, layout of epidemiological and tracking of remedy experiences have been pointed out. a unique function of this e-book is the excellent selection of state-of-the-art overview articles within the numerous fields with many references and the enclosure of the controverse discussions to every article which supplies the reader with a lifely photo at the position of Chlamydia pneumoniae in persistent diseases.
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Extra resources for Chlamydia pneumoniae and Chronic Diseases: Proceedings of the State-of-the-Art Workshop held at the Robert Koch-Institut Berlin on 19 and 20 March 1999
Infect Immun 65: 48324835 23 21. Muhlestein JB, Anderson JL, Hammond EH, Zhao L, Trehan S, Schwobe BS, Carlquist JF (1998) Infection with Chlamydia pneumoniae accelerates the development of atherosclerosis and treatment with azithromycin prevents it in a rabbit model. Circulation 97: 633-636 22. Malinverni R, Kuo CC, Campbell LA, Lee A, Grayston JT (1995) Effects of two antibiotic regimens on course and persistence of experimental Chlamydia pneumoniae (TW AR) pneumonitis. Antimicrobial Agents Chemother 39: 45-49 23.
Thus far, three animal models for C. pneumoniae infection have been evaluated. C. , by intranasal, intravenous and subcutaneous inoculations. Monkey models for C. pneumoniae infection Different monkey species, baboons as well as rhesus and cynomolgus monkeys, have been infected by using different challenge routes with C. pneumoniae, strain TWAR [4, 5]. The infected animals do not develop any clinical disease, both organisms can be recovered from the nasopharynx after inoculation. The infection persisted for a prolonged period and, interestingly, in cynomolgus monkeys the intranasally inoculated agent was demonstrated also in rectal swabs, pointing to a systemic spread .
J Clin Microbiol 35: 620623 16. Kutlin A, Roblin PM, Hammerschlag MR (1998) Antibody response to Chlamydia pneumoniae infection in children with respiratory illness. J Infect Dis 177: 720-724 Discussion Brade: Dr. Christiansen, you said at the beginning that C. pneumoniae is not trafficking along acting filaments like C. trachoma tis does, and accordingly you see these multiple inclusions in cells. But in the slide you showed from your animal models these were fantastic inclusions as they are known from C.