Download Chitin and Chitosan Derivatives: Advances in Drug Discovery by Se-Kwon Kim PDF

By Se-Kwon Kim

A usual long-chain polymer, chitin is the most section of the mobile partitions of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and inner shells of cephalopods. even if, marine crustacean shells are the first assets of the chitin by-product chitosan. Chitin and chitosan are important for varied organic and biomedical purposes, even though they've been restricted through bad solubility long ago. present learn specializes in expanding their solubility and bioactivity via molecular transformations. The ensuing derivatives are receiving a lot consciousness for attention-grabbing homes, equivalent to biocompatibility, biodegradability, and nontoxicity, that cause them to appropriate to be used within the biomedical field.

Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments provides present study tendencies within the synthesis of chitin and chitosan derivatives, their organic actions, and their biomedical purposes. half I discusses simple information regarding the synthesis and characterization of quite a few derivatives, together with the instruction of chitin nanofibers. half II covers chitin and chitosan ameliorations because the foundation for organic purposes. It describes antioxidant, anti inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial actions. half III addresses chemically converted and composite fabrics of chitin and chitosan derivatives for biomedical functions, reminiscent of tissue engineering, nanomedicine, drug supply, and wound dressing.

A must-have reference for newbies and specialists in biotechnology, usual items, fabrics technology, nutraceuticals, and biomedical engineering, this publication provides a variety of organic and biomedical purposes of chitin and chitosan derivatives for drug discovery and development.

Show description

Read Online or Download Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments PDF

Best physical books

The Backbone of History: Health and Nutrition in the Western Hemisphere

This examine gathers skeletal facts on seven easy symptoms of wellbeing and fitness to evaluate continual stipulations that affected people who lived within the Western Hemisphere from 5000 B. C. to the overdue 19th century. symptoms of organic pressure in formative years and of degeneration in joints and in enamel elevated within the numerous millenia earlier than the coming of Columbus as populations moved into much less fit ecological environments.

Self-organization and Pattern-formation in Neuronal Systems Under Conditions of Variable Gravity: Life Sciences Under Space Conditions (Nonlinear Physical Science)

Self-organization and Pattern-formation in Neuronal structures less than stipulations of Variable Gravity: existence Sciences lower than house stipulations” describes the interplay of gravity with neuronal platforms. To bring the fundamental clinical and technological heritage, the constructions of neuronal platforms are defined and systems for gravity learn are provided.

Additional info for Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments

Example text

2001, Davis 2002, Kaneda 2005, Lai et al. 2009). To overcome some of these problems, different modifications were made on the chitosan vector. Chitosan grafted by PEG was shown to have less aggregation and more transfection efficiency. This is mainly because of reduction of opsonization of the chitosan polyplex as well as prolongation of blood circulation of the vector. Zhang et al. have conducted studies to show that pegylated chitosan vectors could not only avoid the clearance by the Kupffer cells but could also increase the rate of transfection of the vector to the liver tumor cells (Zhang et al.

A. Muzzarelli, editors. Springer: Berlin, Heidelberg, pp. 23–53. , P. Ruangsri, K. Suthin, P. Thunyakitpisal, and W. Tachaboonyakiat. 2012. Sodium-phosphorylated chitosan/zinc oxide complexes and evaluation of their cytocompatibility: An approach for periodontal dressing. Journal of Biomaterials Applications 27(4):403–412. , R. Krishnaraj, and T. A Desai. 2001. Evaluation of nanostructured composite collagen–chitosan matrices for tissue engineering. Tissue Engineering 7(2):203–210. Thein-Han, W.

2006). Studies were also conducted to establish that chitosan has antioxidant activity against free radicals and super oxides, such as ferrous oxide. Chitosan with higher degrees of DD and lower Mw has shown to possess more antioxidant activity against super oxides. The metal ion chelating property of chitosan is probably the reason for binding the superoxide radicals and chitosan’s natural antioxidant activity (Peng 1998, Xing et al. 2005). 5 Biomedical Application of Chitosan Owing to characteristics such as biocompatibility, biodegradability, and nontoxicity, chitosan has been used for different biomedical purposes, such as pharmaceutical application, wound healing, and tissue regeneration (Berger et al.

Download PDF sample

Rated 4.68 of 5 – based on 48 votes