By Se-Kwon Kim
A usual long-chain polymer, chitin is the most section of the mobile partitions of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and inner shells of cephalopods. even if, marine crustacean shells are the first assets of the chitin by-product chitosan. Chitin and chitosan are important for varied organic and biomedical purposes, even though they've been restricted through bad solubility long ago. present learn specializes in expanding their solubility and bioactivity via molecular transformations. The ensuing derivatives are receiving a lot consciousness for attention-grabbing homes, equivalent to biocompatibility, biodegradability, and nontoxicity, that cause them to appropriate to be used within the biomedical field.
Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments provides present study tendencies within the synthesis of chitin and chitosan derivatives, their organic actions, and their biomedical purposes. half I discusses simple information regarding the synthesis and characterization of quite a few derivatives, together with the instruction of chitin nanofibers. half II covers chitin and chitosan ameliorations because the foundation for organic purposes. It describes antioxidant, anti inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial actions. half III addresses chemically converted and composite fabrics of chitin and chitosan derivatives for biomedical functions, reminiscent of tissue engineering, nanomedicine, drug supply, and wound dressing.
A must-have reference for newbies and specialists in biotechnology, usual items, fabrics technology, nutraceuticals, and biomedical engineering, this publication provides a variety of organic and biomedical purposes of chitin and chitosan derivatives for drug discovery and development.
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Additional info for Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments
2001, Davis 2002, Kaneda 2005, Lai et al. 2009). To overcome some of these problems, different modifications were made on the chitosan vector. Chitosan grafted by PEG was shown to have less aggregation and more transfection efficiency. This is mainly because of reduction of opsonization of the chitosan polyplex as well as prolongation of blood circulation of the vector. Zhang et al. have conducted studies to show that pegylated chitosan vectors could not only avoid the clearance by the Kupffer cells but could also increase the rate of transfection of the vector to the liver tumor cells (Zhang et al.
A. Muzzarelli, editors. Springer: Berlin, Heidelberg, pp. 23–53. , P. Ruangsri, K. Suthin, P. Thunyakitpisal, and W. Tachaboonyakiat. 2012. Sodium-phosphorylated chitosan/zinc oxide complexes and evaluation of their cytocompatibility: An approach for periodontal dressing. Journal of Biomaterials Applications 27(4):403–412. , R. Krishnaraj, and T. A Desai. 2001. Evaluation of nanostructured composite collagen–chitosan matrices for tissue engineering. Tissue Engineering 7(2):203–210. Thein-Han, W.
2006). Studies were also conducted to establish that chitosan has antioxidant activity against free radicals and super oxides, such as ferrous oxide. Chitosan with higher degrees of DD and lower Mw has shown to possess more antioxidant activity against super oxides. The metal ion chelating property of chitosan is probably the reason for binding the superoxide radicals and chitosan’s natural antioxidant activity (Peng 1998, Xing et al. 2005). 5 Biomedical Application of Chitosan Owing to characteristics such as biocompatibility, biodegradability, and nontoxicity, chitosan has been used for different biomedical purposes, such as pharmaceutical application, wound healing, and tissue regeneration (Berger et al.