By Marc E. Rothenberg
Offers greater than 2200 references to inspire ongoing learn! This distinct quantity synthesizes the most recent breakthroughs within the fields of hypersensitive reaction and chemokines leading to cutting edge paradigms and new innovations in regards to the starting place and remedy of allergic ailments. Considers the organic homes of approximately 60 structurally comparable chemokines and over a dozen receptors! formed to offer an up to date evaluation of molecular constitution, gene rules, organic homes, and sign transduction pathways, Chemokines in Allergic disorder ·documents the emergence of chemokines as a huge tremendous relations of chemoattractant cytokines that advertise the activation and improvement of leukocytes ·illuminates the tactics that keep an eye on leukocyte accumulation ·links chemokines with mobilephone recruitment and activation in allergic ailment ·explores the advantages of pharmaceutical intervention within the chemokine pathway ·covers the elemental biochemistry, molecular biology, and actual constitution of chemokines and their receptors ·describes transcriptional law of chemokine expression ·discusses virally precipitated gene expression as a first-rate set off of allergic responses in young ones ·analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages ·elucidates the mobile community excited about the new release of chemokines in allergic ailments ·highlights pharmaceutical techniques for the advance of chemokine structural analogs, receptor antagonists, and inhibitors of sign transduction ·offers healing thoughts for interfering with chemokines in allergic issues ·and extra! With contributions from forty six the world over revered clinicians, Chemokines in Allergic illness is an integral reference for simple and medical immunologists; allergists; pulmonologists and pulmonary illness experts; physiologists; molecular, mobile, and lung biologists; pediatricians; internists; and graduate and clinical college scholars in those disciplines.
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Headquarters Marcel Dekker, Inc. com The publisher offers discounts on this book when ordered in bulk quantities. For more information, write to Special Sales/Professional Marketing at the headquarters address above. Copyright © 2000 by Marcel Dekker, Inc. All Rights Reserved. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage and retrieval system, without permission in writing from the publisher.
Kim and Hal E. Broxmeyer 227 13. The Induction of Chemokines by Viruses in Allergic States James M. Stark 263 14. Chemokine and Cytokine Cooperativity Ljubov Simson and Paul Stephen Foster 289 15. Chemokine Receptor Signal Transduction Mechanisms Ann Richmond, Wei Yang, and Madhav N. Devalaraja 311 III. Clinical Science of Chemokines in Allergic Disease 16. Chemokines and Disease Andrew D. Luster, Sylvie Abi-Younes, and Andrew M. Tager 339 17. Chemokines in Allergic Asthma Sun Ying and A. B. Kay 383 18.
Special thanks to Victorine Malka. Most important, I am grateful to my wife for her continuous encouragement, love, and support. MARC E. [/PU][DP]2000[/DP]End of Citation Page vii CONTENTS Preface v Contributors xi I. Basic Science of Chemokines and Their Receptors 1. Overview Marc E. Rothenberg and Simon Patrick Hogan 1 2. The Chemokine Family Joost J. Oppenheim, O. M. Zack Howard, and Joseph A. Hedrick 17 3. Chemokine Receptors Philip M. Murphy and Marc E. Rothenberg 53 4. Three-Dimensional Structure of Chemokines Martin J.