By Julia Polak
Using stem cells to assist with lung regeneration and service is a unique treatment that could aid section out the necessity for traditional surgical or pharmacological ways at present hired to regard ailments of the lung or different organs. the current ebook explores all avenues of this new type of therapy, relocating rapidly, yet extensive, from the fundamental technological know-how of lung improvement, to the analyses of other stem cellphone forms on hand for regeneration and directly to the appliance of this data base in preliminary medical trials. during this quantity a stellar staff of researchers converge, from diversified angles, to aid in the direction of clarifying the fundamental mechanisms of lung fix. those variety from uncomplicated innovations of regeneration and lung improvement, the analyses of quite a few cellphone kinds that could be occupied with lung fix, to methods of constructing complicated lung constructions, together with man made and bioartificial lungs. The ebook deals an perception into fix mechanisms of the diseased lung, the position of particular lung niches and offers info on preliminary medical trials in addition to using stem cells as autos for gene treatment. inventive technological facets of assessing stem cellphone engraftment of stem cellphone bioprocessing also are integrated during this quantity.
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Additional info for Cell Therapy for Lung Disease
26. N. H. The extrapulmonary origin of fibroblasts: stem/progenitor cells and beyond. Proc Am Thorac Soc 3(4), 373–376 (2006). 27. , and Mollard, R. Deriving respiratory cell types from stem cells. Curr Stem Cell Res Ther 2(3), 197–208 (2007). 28. Kannan, S. and Wu, M. Respiratory stem cells and progenitors: overview, derivation, differentiation, carcinogenesis, regeneration and therapeutic application. Curr Stem Cell Res Ther 1(1), 37–46 (2006). 29. , and Fine, A. Stem cells in airway smooth muscle: state of the art.
Qxd 14 2/12/2010 5:14 PM Page 14 D. J. Weiss Figure 2: Human b2-microglobulin and cystic fibrosis transmembrane conductance regulator (CFTR)-positive cells can be detected in NOD-SCID mice airways after systemic administration of cord blood mesenchymal stem cells (CB-MSCs). (A and B) NOD-SCID lung sections two weeks and one month after CB-MSC administration, respectively. (C and D) Corresponding higher power images of (A) and (B). Representative photomicrographs from one of four mice per experimental condition.
In addition to the role of endogenous lung stem and progenitor cells in repair of lung injury, increasing information suggests that mature differentiated lung cells may transdifferentiate and change phenotype. 56–61 These mechanisms may also play significant roles in injury or repair from injury. Overall, there remains much to be learned about endogenous stem and lung progenitor cells, including clarification of human counterparts to the cells identified in mouse models. 3. Endogenous Lung Progenitor Cells as Lung Cancer Stem Cells There is substantial interest in the connections between endogenous stem or progenitor cells and cancer stem cells.