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By Claudio De Simone M.D., Giuseppe Famularo M.D. (auth.)

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0 Cl)'I.... 4. The effect of 3-thia fatty acids on the oxidation of 1-14C-palmitate to acid soluble products (mainly ketone bodies) in isolated liver mitochondria from rats fasted for 48 hours (white columns), or from rats fasted for 48 hours and then refed carbohydrate (white bread + 10% sucrose in the drinking water) for 24 hours (black columns). 2 mM) for 30 min. The thia fatty acids used were octyl- to hexadecyl-thioacetic acid. but after 24 hours the level is even higher than in control animals.

Friedman S, Fraenkel G. Reversible enzymatic acetylation of carnitine. Arch Biochem Biophys 1955; 59:491-501. 7. Lindstedt G, Lindstedt S. On the biosynthesis and degradation of carnitine. Biochem Biophys Res Commun 1961; 6:319-323. 8. Bremer J. Carnitine precursors in the rat. Biochim Biophys Acta 1962; 57:327-335. 9. Bremer J. Carnitine in intermediary metabolism. Reversible acetylation of carnitine by mitochondria. J BioI Chern 1962; 237:2228-2231. The Role of Carnitine in Cell Metabolism 25 10.

Induction of ketogenesis and fatty acid oxidation by glucagon and cyclic AMP in cultured hepatocytes from rabbit fetuses. Evidence for a decreased sensitivity of carnitine palmitoyltransferase I to malonyl-CoA inhibition after glucagon or cyclic AMP treatment. Biochem J 1989; 264:93-100. 155. Guzman M, Castro J. Okadaic acid stimulates carnitine palmitoylttransferase I and palmitate oxidation in isolated rat hepatocytes. FEBS Lett 1991; 291:105-108. 156. Guzman M, Velasco G, Castro J et al. Inhibition of carnitine palmitoyltransferase I by hepatocyte swelling.

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