By H. C. Hemker (auth.), C. Th. Smit Sibinga, P. C. Das, J. J. van Loghem (eds.)
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Management of patients with inherited blood coagulation defects, ibid, p. 371. A. Kahn With the development of plastic blood collection bags that permit several containers to be integrally connected and sterilized as a unit, separating whole blood into its components became possible. The availability of blood components fostered their utilization and the concept of 'component therapy', or transfusion of the specific fraction of the blood which the patient lacks, has become an increasingly important part in today's practice of blood transfusion.
They move out factor V-a with the release reaction and they flip-flop membrane. You can differentiate between these two things by looking at the platelet procoagulant activity in presence of a large amount of factor V-a.
As a consequence a number of protocols for prophylactic platelet transfusion are currently used. In our hospital patients with platelet counts of less than 10,000 per mm 3 (due to impaired platelet production) are considered candidates for such prophylactic platelet transfusions. g. cytomegaly), graft vs host reaction and septicemia due to bacterial contamination. Alloimmunization to platelet antigens with the development of clinical resistance is likely to be more frequent and may have serious consequences when platelet transfusions are frequently used.