Download Autoimmune Reactions by Sudhir Paul (auth.), Sudhir Paul (eds.) PDF

By Sudhir Paul (auth.), Sudhir Paul (eds.)

Autoimmune Reactions tackles basic questions about how the immune procedure can ruin invading microbial pathogens with no inflicting harm to itself and different "self" structures. The authoritative specialists writing right here discover the mechanistic features of such autoimmune ailments as lupus, rheumatoid arthritis, diabetes, and autoimmune thyroid disorder, and the place attainable delineate how malfunctioning immunological mechanisms can result in scientific signs. additionally they speak about attainable basic mechanisms of autoimmune disease-e.g., molecular mimicry and dysfunctional antigen presentation-and their present boundaries as unifying reasons of the illnesses defined. furthermore, proof for novel immunological phenomena, together with antibody catalysis and the penetration of cells by means of antibodies, is reviewed, and their attainable organic results are pointed out. The publication additionally significantly surveys the thoughts and examine that are meant to ultimately let improvement of palliatives and treatments for autoimmune ailments, in addition to methods to the long-standing challenge of self-nonself discrimination via the immune system.

the excellent, insightful assessment supplied in Autoimmune Reactions constitutes the recent typical reference for all working towards autoimmunologists, molecular immunologists, mobile and molecular pathologists, and scientific immunologists who have to stay on the state of the art of analysis on autoimmune sickness this present day.




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36. Silberstein, L. , Jefferies, L. , Moore, J. , Nowell, P. , et al. (1991) Variable region gene analysis of pathologic human autoantibodies to the related I and I red blood cell antigens. Blood 78, 2372-2379. 37. Stevenson, F. , Glennie, M. , Jones, D. , et al. (1986) Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors. Blood 68,430-437. 38. Potter, K. , Williams, R. , Byres, L. , et al. (1993) Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.

1. Immunol. 146, 4385-4392. 36. Silberstein, L. , Jefferies, L. , Moore, J. , Nowell, P. , et al. (1991) Variable region gene analysis of pathologic human autoantibodies to the related I and I red blood cell antigens. Blood 78, 2372-2379. 37. Stevenson, F. , Glennie, M. , Jones, D. , et al. (1986) Antibodies to shared idiotypes as agents for analysis and therapy for human B cell tumors. Blood 68,430-437. 38. Potter, K. , Williams, R. , Byres, L. , et al. (1993) Molecular characterization of a cross-reactive idiotope on human immunoglobulins utilizing the VH4-21 gene segment.

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