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By Herbert Begemann

-Enhanced sixth variation includes extra illustrations and documented figures

-A excellent reference for hematological and oncological departments and the clincal labortory

-Classified findings from the realm health and wellbeing Organization

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6. Myeloblasts and promyelocytes ~ 1,250x Myeloblasts are the youngest precursors of granulopoiesis definable by light microscopy. Their diameter ranges between 12 and 20 Ilm. Smaller forms are known as micromyeloblasts (08-12 Ilm). The cytoplasmic border is strongly basophil; but transitions from light blue to deep blue occur. By the usual panoptic staining, the cytoplasm is agranular, but in maturer cells, commencing granulation and thus transition to promyelocytes is demonstrable (cell 9). The peroxidase reaction is mostly negative but undoubtedly, agranular myeloblasts exist that are peroxidase-positive.

The coarse promyelocytic granulation disappears. From it develops the typical fine neutrophil or coarse basophil or eosinophil (see Fig. 9) granulation. The basophilia of the cytoplasm lightens from the nucleus and its staining affinity changes to acidophil. At the same time, the nuclear chromatin becomes coarser. Nucleoli are only rarely demonstrable. The myelocytes present the main contingent of all granulocytopoietic cells of the bone marrow. 38 As maturation continues, the chromatin framework of the nucleus becomes still more coarse, lumpy and denser.

Furthermore, anisocytosis and the different diameter of the erythrocytes are obvious. 1. lm). 5. Microspherocytes. lm) but which are densely filled with hemoglobin and are thicker than normal erythrocytes thus approximating to a globular form. They are typical of congenital hemolytic icterus (spherocytic anemia) but are also encountered in acquired hemolytic anemias. 2. Hypochromic erythrocytes in iron deficiency anemia. The diameter is normal. The scanty hemoglobinization is remarkable and may be so poor as to leave only thin rings of hemoglobin (anulocytes).

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