Download Anemia in the Elderly by Lodovico Balducci, William B. Ershler, John M. Bennett PDF

By Lodovico Balducci, William B. Ershler, John M. Bennett

Anemia within the aged has been competently outlined because the silent epidemic, representing three million humans within the usa elderly sixty five years and older. prevalence and incidence of this raise with age. It differs in its etiology, pathogenesis and therapy from anemia in teenagers and more youthful adults. Anemia is linked to diminished survival, elevated hazard of sensible dependence and hospitalization, elevated possibility of congestive center failure and level renal illness and cognitive problems. nearly 70% of anemia in older participants is reversible.

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2; 2) . Thus, the amount of sTfR protein is proportional to the size of the erythroid marrow (6). However, in states of iron deficiency, the TfR gene is upregulated, and increased numbers of TfR are expressed on the surface of developing erythroid cells. 2, the appearance of iron deficiency requires a progressive sequence of stages before there is frank anemia. The first stage is negative iron balance during which there is more iron leaving the body than is coming in. If this state persists, there is a gradual loss of iron stores and that will be reflected in a fall in the serum ferritin.

In the pregnant woman, iron deficiency can lead to low birth weight infants. Importantly, in the elderly, iron deficiency is frequently a sign of underlying pathology. 1. The next sections examine these various tests in more detail. Transferrin (Total Iron-Binding Capacity or TIBC) Transferrin is the major iron transport protein in the body. Its role is to shuttle iron from storage sites and the gut to the erythroid marrow where the iron that’s carried can be used for hemoglobin synthesis. Transferrin is the only major iron transporter to parenchymal cells.

2005;28(11 Suppl Proceedings):15–9 15. Balducci L, Hardy CL, Lyman GH: Hemopoiesis and aging. Cancer Treat Res. 2005;124:109–31 16. Lee SJ, Lindquist K, Segal MR et al: Development and validation of a prognostic index for 4-year mortality in older adults. JAMA. 2006 Feb 15;295(7):801–8. Erratum in: JAMA. 2006 Apr 26;295(16):1900 17. Balducci L, Extermann M: The assessment of the older cancer patient. In: Balducci L, Lyman GH, Ershler WB, Extermann M: Comprehensive Geriatric Oncology 2nd edition, Taylor and Francis, London, 2004 18.

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