Download Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung PDF

By Kian Fan Chung

During this booklet, top researchers in medication and molecular pharmacology clarify the mobile mechanisms that keep watch over airway gentle muscle. The capacity wherein those are disrupted in sickness, and the pharmacologic options during which they're transformed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the freshest details on one of many center physiological approaches in airway affliction, and gives insights into present and destiny techniques to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates newest learn to bronchodilator therapyMulti-contributed textual content, co-coordinated via of the prime experts within the box.

Show description

Read or Download Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology PDF

Similar pulmonary & thoracic medicine books

Clinical Respiratory Medicine

A necessary software for all physicians who deal with sufferers with respiration sickness

Atlas of Endoscopic Major Pulmonary Resections

Video-assisted significant pulmonary resections are rising in popularity, because it turns into noticeable that minimally invasive surgical procedure is useful when it comes to lowered postoperative soreness, shorted sanatorium remain, shorter restoration and higher compliance to adjuvant chemotherapy, with no compromising oncological ideas.

Physiotherapie bei chronischen Atemwegs- und Lungenerkrankungen: Evidenzbasierte Praxis

Das Praxisbuch bietet eine Anleitung zur physiotherapeutischen Untersuchung und nicht medikamentösen Behandlung von chronischen Atemwegs- und Lungenerkrankungen sowie respiratorischen Problemen. Der Grundlagen-Teil erläutert verständlich die Anatomie und Biomechanik des Atembewegungsapparats, die Physiologie der Atmung, die Herzfunktion sowie die autonome Funktion bei chronischen Atemwegserkrankungen.

Morbid Obesity in Adolescents: Conservative Treatment and Surgical Approaches

Because the world wide incidence of morbid weight problems between teenagers maintains to upward thrust, fresh years have obvious a wide bring up within the functionality of adolescent bariatric surgical procedure. whereas surgical intervention frequently turns into helpful while conservative weight reduction remedies have failed, no criteria in regards to the post-operative routine and long term administration of adolescent sufferers were validated.

Extra info for Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Example text

Hedges, J. , Dechert, M. , Yamboliev, I. A. et al. (1999). A role for p38(MAPK)/HSP27 pathway in smooth muscle cell migration. J Biol Chem 274, 24211–24219. Hedges, J. , Oxhorn, B. , Carty, M. et al. (2000). Phosphorylation of caldesmon by ERK MAP kinases in smooth muscle. Am J Physiol 278, C718–C726. Hirshman, C. A. and Emala, C. W. (1999). Actin reorganization in airway smooth muscle cells involves Gq and Gi-2 activation of Rho. Am J Physiol 277, L653–L661. Hirst, S. , Twort, C. H. C. and Lee, T.

1996). , 1998). , 1998). , 2006). , 2004). The idea of functional differentiation among different actin isoforms was strengthened by studies of smooth muscle cytoskeletal organization by Small and colleagues, who observed distinct subsets of actin filaments localized to different physical domains within the smooth muscle cell (Small, 1995). They reported ‘cytoskeletal’ ␤-actin to be selectively localized to the cytoplasmic dense bodies, the membrane adhesion sites, and the longitudinal channels linking consecutive dense bodies, which are also occupied by filamin and desmin.

8 Future directions To understand the multifaceted problem of airway hyperresponsiveness in asthma, an integrative understanding that brings together a diversity of factors is essential. We have outlined here an emerging picture of smooth muscle biophysics as it relates to excessive airway narrowing in asthma, but we need to keep in mind that asthma is a chronic inflammatory disorder; therefore, understanding the impact of inflammatory remodelling of the airway wall and the airway smooth muscle cell on disease presentation is vital.

Download PDF sample

Rated 4.47 of 5 – based on 38 votes