Download Advances in the Immunopathogenesis of Multiple Sclerosis by P. A. Muraro, A. Lugaresi, D. Gambi (auth.), D. Gambi, P. A. PDF

By P. A. Muraro, A. Lugaresi, D. Gambi (auth.), D. Gambi, P. A. Muraro, A. Lugaresi, U. Ecari (eds.)

P.A. MURARO, A. LUGARESI, D. GAMBI some of the pathological elements of a number of sclerosis (MS) lesions were recognized for over a century. it's only lately, besides the fact that, that diversified styles of demyelination were associated with special pathways of immune-mediated tissue destruction. specifically, the inter-individual heterogeneity of MS lesions has advised that diversified mechanisms might act in several sufferers, accounting for the range saw in scientific direction, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and reaction to immunomodulatory remedies. to supply an outline of the elemental mechanisms most likely inquisitive about MS lesion initiation and improvement, a world assembly used to be prepared within the context of the once a year Congress of the Italian Neuroimmunology organization (AINI), held on the college of Chieti, in Chieti Italy on 29 October 1998. The excessive commonplace of shows brought on us to record them in prolonged shape, to spotlight fresh seasoned­ gress within the realizing of easy mechanisms maintaining MS immuno­ pathogenesis. A principal position within the attainable mechanisms resulting in myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. stories at the myelin antigen-specific T mobile repertoire have contributed major advances to our wisdom of autoimmunity (Chapters 1,2).

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Science 270:593598 15. Neumann H, Cavalie A, Jenne DE, Wekerle H (1995) Induction of MHC class I genes in neurons. Science 269:549-552 16. Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H (1997) MHC class I gene expression in single neurons of the central nervous system: Differential regulation by interferon-y and tumor necrosis factor-a. J Exp Med 185:305-316 17. Corriveau RA, Huh GS, Shatz CJ (1998) Regulation of class I MHC gene expression in the developing and mature CNS by neural activity.

Production and secretion of neurotrophins are also closely associated with electrical activity of neurons [14]. In our brain tissue culture model, nerve growth factor (NGF), brain-derived growth factor (BDNF) and neurotrophin-3 (NT-3) were independently capable of downregulating IFN-y-mediated expression of MHC class II on microglia [13]. NGF and NT-3, but not BDNF, directly acted on microglia cells isolated in culture and inhibited MHC class II expression via the p7S neurotrophin receptor [13].

J Neurosci 16:2508-2521 Kerschensteiner M, Gallmeier E, Behrens L, Klinkert WEF, Kolbeck R, Hoppe E, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R (1999) Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation? J Exp Med 189:865-870 Chapter 6 Levels of platelet-activating factor in cerebrospinal fluid and plasma of patients with relapsing-remitting multiple sclerosis M. ARESE, 1. CALLEA, C.

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