By Franz Joel Leong, Veronique Dartois, Thomas Dick
An annual demise toll of two million, coupled with emerging drug resistance, highlights the necessity for the improvement of latest medications, larger diagnostics, and a tuberculosis (TB) vaccine. Addressing those key concerns, a colour Atlas of Comparative Pathology of Pulmonary Tuberculosis introduces TB histopathology to the non-histopathologists, scholars, scientists, and medical professionals operating, studying, and instructing within the box of TB. It comprises a hundred colour images and illustrations that deliver readability to the knowledge provided. The atlas takes the weird procedure of masking a number of species histopathology, arguably the 1st and particularly probably the one source to take action. It presents an easy, annotated, and visible presentation of the comparative histopathology of TB in human and animal types. The editors have compiled details that is helping TB scientists to tell apart among the positive aspects of all significant animal types on hand and to exploit them with their strengths and barriers in brain. The publication presents information for choosing the easiest animal model(s) to respond to particular questions and to check the efficacy of drug applicants.
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Additional resources for A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
Secretion of mucus in the lung, as in the intestines, is thought to serve a protective function, but excess secretion may obliterate the air passage, especially in small scarred airways. 5â•… Normal bronchial epithelium (H&E, HP). Bronchial epithelium showing a columnar epithelium displaying a dynamic, but constant cell population composed of ciliated cells and very occasional goblet cells (arrows) at the inner surface and multipotent basal cells attached to the basal membrane. Anatomy and Histology of the Human Lung â•›â†œ◾â†œæ¸€ 41 Basal Cells The basal cell is the progenitor of all ciliated and nonciliated cells in the bronchial mucosa.
2006. Drug discovery and development: Technology in transition. Philadelphia: Churchill Livingstone Elsevier. , and Dick, T. 2010. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source dependant growth inhibitors deprived of in vivo efficacy. Nature Communications (submitted for review). , and Haag, H. 2006. High-throughput screening. In Drug discovery and development: Technology in transition, ed. P. Rang, 99–120. Philadelphia: Churchill Livingstone Elsevier. World Health Organization.
Normal bronchiolus and adjacent alveoli expressing thyroid transcription factor (TTF-1) in both the bronchial and alveolar cells.