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By Nicole von Steinbüchel, Alexander Steffen, Marc Wittmann

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Lg) reversed the decreasing effect of ATII (2 flg) on apomophine stereotypy. Thus, methylation of the hydroxyl group of Tyr of [Sar 1] ATII produced an active analogue (sarmesin), which behaved as an ATII-receptor antagonist, whose effect on apomorphine stereotypy was more pronounced than that of sarilesin, a peptide ATII receptor antagonist. In conclusion, all the three drugs tested (sarmesin, sarilesin and Losartan) influenced apomorphine stereotypy and reversed the effect of ATII on stereotypy.

ES/13 MATERNAL DEPRIVATION IN THE BROWN NORWAY RAT RESULTS IN LONG-TERM ALTERATIONS OF THE CORTICOSTEROID SYSTEM AND BEHAVIOR. 0. Workel, A. R. S. Oitzl. Box 9503, 2300 RA Leiden, The Netherlands Early life experience by maternal separation may exert life long alterations in the neuroendocrine and behavioral stress response. The main regulators of the stress response are corticosteroid hormones secreted by the adrenal gland. Corticosterone (CORT), the main corticosteroid in rats, exerts its action via binding to high (MR) and low affinity receptors (GR) in the brain, controlling its own release by feedback action and thereby maintaining homeostasis and adaptation to stress.

Piras, and G. DiChiara. Department of Toxicology, University of Cagliari. Viale A. Diaz 182, 09126 Cagliari, ITALY Roman High-Avoidance (RHA) and Roman Low-Avoidance (RLA) rats are selected and bred for respectively rapid versus poor acquisition of two-way avoidance behavior. This selection process has led to many other behavioral differences related to emotional factors, RLA rats being emotionally more reactive. ) on the release of serotonin (5-HT) in the prefrontal cortex (PFCx) and fronto-parietal cortex (FPCx) in both rat lines.

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